Metabolism of cyclamate and its conversion to cyclohexylamine.
نویسنده
چکیده
Since cyclamates were first introduced in the early 1950s, arguments have raged over the potential carcinogenicity of this artificial sweetener. Concern over the safety of cyclamates arises from observations that some individuals and experimental animals can metabolize cyclamate to cyclohexylamine and that cyclohexylamine has been shown to produce testicular atrophy in experimental animals. This study examines the absorption, excretion, and metabolism of cyclamate, particularly its conversion to cyclohexylamine. In addition, the potential toxicity and pharmacology of cyclohexylamine are discussed.
منابع مشابه
Gut Flora in the Metabolism of Cyclamate
1. ["'C]Cyclamate was not metabolized when incubated with the liver, spleen, kidney or blood of rats or rabbits kept on a cyclamate-containing diet, and that had become converters of cyclamate into cyclohexylamine. 2. ["'C]Cyclamate was converted into cyclohexylamine when incubated under anaerobic conditions with the contents of the caecum, colon or rectum or with the faeces of cyclamate-pretre...
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Continuous oral administration of sodium cyclamate(CHS-Na) to guinea pig caused the gradual increase of urinary excretion of cyclohexylamine(CHA) after a certain period. The amount of CHA excreted was not only different in individuals, but also dependent on each experiment. It was diminished when CHS-Na was administered orally with antibiotics or intraperitoneally. It was shown from the incubat...
متن کاملThe fate of cyclamate in man and other species.
1. (14)C-labelled cyclamate has been administered to guinea pigs, rabbits, rats and humans. When given orally to these species on a cyclamate-free diet, cyclamate is excreted unchanged. In guinea pigs some 65% of a single dose is excreted in the urine and 30% in the faeces, the corresponding values for rats being 40 and 50%, for man, 30-50% and 40-60%, and for rabbits, 90 and 5%, the excretion ...
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Renwick & Williams (1972) showed that the gut flora of rats chronically fed with cyclamate acquire the ability to convert cyclamate into cyclohexylamine by splitting the N-S bond, although this did not occur in all rat colonies (Drasar et al., 1970). The splitting of the N-S bond in saccharin could occur similarly to form 2-sulphobenzamide. To investigate the possibility of similar variations i...
متن کاملLong-term toxicity and carcinogenicity study of cyclamate in nonhuman primates.
Twenty-one monkeys (cynomolgus, rhesus, African green) were fed cyclamate (100 mg/kg and 500 mg/kg) in the diet five times per week from a few days after birth and continuing for up to 24 years. Malignant tumors were diagnosed in three 24-year-old cyclamate monkeys; these were metastatic colon carcinoma (rhesus; 500 mg/kg), metastatic hepatocellular carcinoma (cynomolgus; 500 mg/kg), and a smal...
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ورودعنوان ژورنال:
- Diabetes care
دوره 12 1 شماره
صفحات -
تاریخ انتشار 1989